TY - JOUR
KW - Adult
KW - Alanine
KW - Amino Acid Substitution
KW - Aspartic Acid
KW - Cell Adhesion Molecules, Neuronal
KW - DNA Mutational Analysis
KW - Female
KW - Genetic Markers
KW - Genetic Predisposition to Disease
KW - Genetic Testing
KW - genotype
KW - Humans
KW - Immunity, Innate
KW - leprosy
KW - Male
KW - Middle Aged
KW - Nerve Growth Factors
KW - Peripheral nerves
KW - Peripheral Nervous System Diseases
KW - Polymorphism, Single Nucleotide
KW - RNA, Messenger
KW - Up-Regulation
AU - Cardoso C
AU - Martinez AN
AU - Guimarães PEM
AU - Mendes CT
AU - Pacheco A
AU - Oliveira RB
AU - Teles RMB
AU - Illarramendi X
AU - Pereira Sampaio E
AU - Sarno E
AU - Dias-Neto E
AU - Moraes M
AB - <p>Leprosy is the major cause of non-traumatic neuropathy. Herein, we investigated the role of ninjurin 1, an adhesion molecule involved in nerve regeneration in leprosy. Our results demonstrated that M. leprae stimulates in vitro up-regulation of ninjurin mRNA in cultured Schwann and blood cells as well as in vivo mRNA and protein expression in leprosy nerve biopsies. A polymorphism (asp110ala) was investigated in a case-control study (1123 individuals) and no association was found with leprosy per se or with disseminated forms. Nevertheless, ala110 was associated with functional nerve impairment (OR=2.42; p=0.02 for ala/ala) and with lower mRNA levels. Our data suggests that asp110ala could be a valuable genetic marker of nerve damage in leprosy.</p>
BT - Journal of neuroimmunology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/17825431?dopt=Abstract
DA - 2007 Oct
DO - 10.1016/j.jneuroim.2007.07.015
IS - 1-2
J2 - J. Neuroimmunol.
LA - eng
N2 - <p>Leprosy is the major cause of non-traumatic neuropathy. Herein, we investigated the role of ninjurin 1, an adhesion molecule involved in nerve regeneration in leprosy. Our results demonstrated that M. leprae stimulates in vitro up-regulation of ninjurin mRNA in cultured Schwann and blood cells as well as in vivo mRNA and protein expression in leprosy nerve biopsies. A polymorphism (asp110ala) was investigated in a case-control study (1123 individuals) and no association was found with leprosy per se or with disseminated forms. Nevertheless, ala110 was associated with functional nerve impairment (OR=2.42; p=0.02 for ala/ala) and with lower mRNA levels. Our data suggests that asp110ala could be a valuable genetic marker of nerve damage in leprosy.</p>
PY - 2007
SP - 131
EP - 8
T2 - Journal of neuroimmunology
TI - Ninjurin 1 asp110ala single nucleotide polymorphism is associated with protection in leprosy nerve damage.
VL - 190
SN - 0165-5728
ER -