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Lack of effects of the TNF-alpha and IL-10 gene polymorphisms in Mexican patients with lepromatous leprosy.

Abstract

Several human genetic variants have been associated with susceptibility or resistance to leprosy. The aim of this study was to assess whether gene polymorphisms of -308 G/A TNF-alpha and -819 T/C IL-10 are associated with lepromatous leprosy in Mexican mestizos patients from northwest Mexico. We genotyped these polymorphisms by means of polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLPs) in 68 patients with lepromatous leprosy and 144 healthy Mexican Mestizos controls. We found that the -308G TNF-alpha allele was predominant in both cases (94.3%) and controls (92.3%) without statistical significance and the frequencies of -819C IL-10 allele were also similar for the cases (56.0%) and controls (59.0%). These negative findings suggest that other genes or polymorphisms may be important in the susceptibility to leprosy infection in the Mexican mestizos.

More information

Type
Journal Article
Author
Velarde Félix JS
Cázarez-Salazar S
Ríos-Tostado JJ
Flores-Garcia A
Rangel-Villalobos H
Murillo-Llanes J
Year of Publication
2012
Journal
Leprosy review
Volume
83
Issue
1
Number of Pages
34-9
Date Published
2012 Mar
Language
eng
ISSN Number
0305-7518
Alternate Journal
Lepr Rev
Publication Language
eng