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Publication

Innate immune responses in leprosy.

Abstract

Leprosy is an infectious disease that may present different clinical forms depending on host immune response to . Several studies have clarified the role of various T cell populations in leprosy; however, recent evidences suggest that local innate immune mechanisms are key determinants in driving the disease to its different clinical manifestations. Leprosy is an ideal model to study the immunoregulatory role of innate immune molecules and its interaction with nervous system, which can affect homeostasis and contribute to the development of inflammatory episodes during the course of the disease. Macrophages, dendritic cells, neutrophils, and keratinocytes are the major cell populations studied and the comprehension of the complex networking created by cytokine release, lipid and iron metabolism, as well as antimicrobial effector pathways might provide data that will help in the development of new strategies for leprosy management.

More information

Type
Journal Article
Author
Pinheiro RO
Schmitz V
Silva BJA
Dias AA
Souza BJ
Mattos Barbosa MG
Almeida Esquenazi D
Pessolani MCV
Sarno EN
Year of Publication
2018
Journal
Frontiers in immunology
Volume
9
Number of Pages
518
Language
eng
ISSN Number
1664-3224
DOI
10.3389/fimmu.2018.00518
Alternate Journal
Front Immunol
Publication Language
eng