01521nas a2200229   4500000000100000008004100001100001500042700001400057700002100071700001200092700001300104700001600117700002400133700001600157700001200173245004000185856008000225300000800305490000600313520095800319022001401277       2018                            d1 aPinheiro R1 aSchmitz V1 aAndrade Silva BJ1 aDias AA1 aSouza BJ1 aBarbosa MGM1 aAlmeida Esquenazi D1 aPessolani M1 aSarno E00aInnate immune responses in leprosy.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882777/pdf/fimmu-09-00518.pdf  a5180 v93 a<p>Leprosy is an infectious disease that may present different clinical forms depending on host immune response to . Several studies have clarified the role of various T cell populations in leprosy; however, recent evidences suggest that local innate immune mechanisms are key determinants in driving the disease to its different clinical manifestations. Leprosy is an ideal model to study the immunoregulatory role of innate immune molecules and its interaction with nervous system, which can affect homeostasis and contribute to the development of inflammatory episodes during the course of the disease. Macrophages, dendritic cells, neutrophils, and keratinocytes are the major cell populations studied and the comprehension of the complex networking created by cytokine release, lipid and iron metabolism, as well as antimicrobial effector pathways might provide data that will help in the development of new strategies for leprosy management.</p>
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