IL8 and IL17A polymorphisms associated with multibacillary leprosy and reaction type 1 in a mixed population from southern Brazil.

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TitleIL8 and IL17A polymorphisms associated with multibacillary leprosy and reaction type 1 in a mixed population from southern Brazil.
Publication TypeJournal Article
AuthorsAquino JS, Ambrosio-Albuquerque EP, Alves HV, Macedo LC, Visentainer L, Sell AM, Visentainer JEL
Abbrev. JournalAnn. Hum. Genet.
JournalAnnals of human genetics
Year of Publication2018
Publication Languageeng
KeywordsGenetic polymorphisms, Interleukin-17, Interleukin-8, Leprosy, Reactional episodes
Abstract

We evaluated the influence of the IL8 T-738A (nonidentified rs), IL8 T-353A (rs4073), IL17A G197A (rs2275913), and IL17F T7488C (rs763780) single-nucleotide polymorphisms on leprosy. The AA genotype of IL8 T-353A was observed as a risk factor for multibacillary leprosy, regardless of gender and age-of-onset of disease, considering the recessive model (OR, 3.8; 95% CI, 1.1-13.5; P, 0.023). Furthermore, the AA genotype of IL17A G197A was associated with leprosy type 1 reaction (OR, 2.4; 95% CI, 1.1-5.1; P, 0.026) when compared to the group without reaction, which was adjusted for gender and age-of-onset of disease by the model log additive. These results indicate association of IL8 and IL17A polymorphisms with the progression to multibacillary leprosy and with the type 1 reaction, respectively.

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/30303246?dopt=Abstract

DOI10.1111/ahg.12291
Grant List / / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior /
/ / Conselho Nacional de Desenvolvimento Científico e Tecnológico /
/ / Fundação Araucária do Estado do Paraná /
Proc. n.00639/99-DEG-UEM / / Laboratory of Immunogenetics-UEM /