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IL8 and IL17A polymorphisms associated with multibacillary leprosy and reaction type 1 in a mixed population from southern Brazil.

Abstract

We evaluated the influence of the IL8 T-738A (nonidentified rs), IL8 T-353A (rs4073), IL17A G197A (rs2275913), and IL17F T7488C (rs763780) single-nucleotide polymorphisms on leprosy. The AA genotype of IL8 T-353A was observed as a risk factor for multibacillary leprosy, regardless of gender and age-of-onset of disease, considering the recessive model (OR, 3.8; 95% CI, 1.1-13.5; P, 0.023). Furthermore, the AA genotype of IL17A G197A was associated with leprosy type 1 reaction (OR, 2.4; 95% CI, 1.1-5.1; P, 0.026) when compared to the group without reaction, which was adjusted for gender and age-of-onset of disease by the model log additive. These results indicate association of IL8 and IL17A polymorphisms with the progression to multibacillary leprosy and with the type 1 reaction, respectively.

More information

Type
Journal Article
Author
Aquino JS
Ambrosio-Albuquerque EP
Alves HV
Macedo LC
Visentainer L
Sell AM
Visentainer JEL
Year of Publication
2018
Journal
Annals of human genetics
Language
eng
ISSN Number
1469-1809
DOI
10.1111/ahg.12291
Alternate Journal
Ann. Hum. Genet.
Publication Language
eng