@article{32439,
  keywords = {leprosy, Genetic polymorphisms, Interleukin-17, Interleukin-8, Reactional episodes},
  author = {Aquino JS and Ambrosio-Albuquerque EP and Alves HV and Macedo LC and Visentainer L and Sell AM and Visentainer JEL},
  title = {IL8 and IL17A polymorphisms associated with multibacillary leprosy and reaction type 1 in a mixed population from southern Brazil.},
  abstract = {<p>We evaluated the influence of the IL8 T-738A (nonidentified rs), IL8 T-353A (rs4073), IL17A G197A (rs2275913), and IL17F T7488C (rs763780) single-nucleotide polymorphisms on leprosy. The AA genotype of IL8 T-353A was observed as a risk factor for multibacillary leprosy, regardless of gender and age-of-onset of disease, considering the recessive model (OR, 3.8; 95% CI, 1.1-13.5; P, 0.023). Furthermore, the AA genotype of IL17A G197A was associated with leprosy type 1 reaction (OR, 2.4; 95% CI, 1.1-5.1; P, 0.026) when compared to the group without reaction, which was adjusted for gender and age-of-onset of disease by the model log additive. These results indicate association of IL8 and IL17A polymorphisms with the progression to multibacillary leprosy and with the type 1 reaction, respectively.</p>
},
  year = {2018},
  journal = {Annals of human genetics},
  issn = {1469-1809},
  doi = {10.1111/ahg.12291},
  language = {eng},
}