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Hematological alterations in lepromatous leprosy: A cross-sectional observational study.

Abstract

BACKGROUND: Dapsone has been the mainstay for the treatment of leprosy since its discovery in the 1940s. However, hematological disturbances are not uncommon in leprosy patients on daily dapsone therapy. Hence, the present study was conducted to document the hematologic alterations observed in lepromatous leprosy patients treated with Dapsone 100 mg daily.

METHODOLOGY: A cross-sectional observational study was conducted amongst 32 lepromatous leprosy patients treated with Dapsone 100 mg daily. A complete hemogram was conducted for all the study recruits. The test results were compared against the standard average values for adults for the given variables. The one sample t-test was employed to compare the difference between the study values and the standard normal values for adults. The statistical significance was considered at p < 0.05.

RESULTS: The study reveals a marked decrease in hemoglobin concentration in patients on dapsone, 100 mg daily. Other hematological alterations found were reduced platelet count, reduced mean platelet volume, reduced Hematocrit, reduced Mean Corpuscular hemoglobin, reduced Mean Corpuscular hemoglobin concentration. (p < 0.05).

CONCLUSION: Treatment of lepromatous leprosy with 100 mg daily Dapsone therapy may lead to hematological alterations. These findings are suggestive of dapsone-induced hemolysis.

More information

Type
Journal Article
Author
Gupta B
Gupta S
Chaudhary M
Raj TA
Awan K
Patil S
Year of Publication
2019
Journal
Disease-a-month : DM
Number of Pages
100919
Date Published
11/2019
Language
eng
ISSN Number
1557-8194
DOI
10.1016/j.disamonth.2019.100919
Alternate Journal
Dis Mon
PMID
31796205
Publication Language
eng