01986nas a2200241 4500000000100000008004100001260001200042653002000054653001200074653001400086653001200100653001900112100001200131700001200143700001600155700001100171700001100182700001200193245009300205300001100298520142100309022001401730 2019 d c11/201910aCross-sectional10aDapsone10aHemolysis10aleprosy10aPlatelet count1 aGupta B1 aGupta S1 aChaudhary M1 aRaj TA1 aAwan K1 aPatil S00aHematological alterations in lepromatous leprosy: A cross-sectional observational study. a1009193 a

BACKGROUND: Dapsone has been the mainstay for the treatment of leprosy since its discovery in the 1940s. However, hematological disturbances are not uncommon in leprosy patients on daily dapsone therapy. Hence, the present study was conducted to document the hematologic alterations observed in lepromatous leprosy patients treated with Dapsone 100 mg daily.

METHODOLOGY: A cross-sectional observational study was conducted amongst 32 lepromatous leprosy patients treated with Dapsone 100 mg daily. A complete hemogram was conducted for all the study recruits. The test results were compared against the standard average values for adults for the given variables. The one sample t-test was employed to compare the difference between the study values and the standard normal values for adults. The statistical significance was considered at p < 0.05.

RESULTS: The study reveals a marked decrease in hemoglobin concentration in patients on dapsone, 100 mg daily. Other hematological alterations found were reduced platelet count, reduced mean platelet volume, reduced Hematocrit, reduced Mean Corpuscular hemoglobin, reduced Mean Corpuscular hemoglobin concentration. (p < 0.05).

CONCLUSION: Treatment of lepromatous leprosy with 100 mg daily Dapsone therapy may lead to hematological alterations. These findings are suggestive of dapsone-induced hemolysis.

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