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Gene Association with Leprosy: A Review of Published Data

Abstract

Leprosy is a chronic infectious disease caused by an obligate intracellular bacterium known as Mycobacterium leprae. Exposure to the bacillus is necessary, but this alone does not mean an individual will develop clinical symptoms of the disease. In recent years, several genes have been associated with leprosy and the innate immune response pathways converge on the main hypothesis that genes are involved in the susceptibility for the disease in two distinct steps: for leprosy per se and in the development of the different clinical forms. These genes participate in the sensing, main metabolic pathway of immune response activation and, subsequently, on the evolution of the disease into its clinical forms. The aim of this review is to highlight the role of innate immune response in the context of leprosy, stressing their participation in the signaling and targeting processes in response to bacillus infection and on the evolution to the clinical forms of the disease.

 

 

 

More information

Type
Journal Article
Author
Mazini PS
Alves HV
Reis ÂG
Lopes AP
Sell AM
Santos-Rosa M
Visentainer JEL
Rodrigues-Santos P
Year of Publication
2016
Journal
Frontiers in Immunology
Language
eng
Call Number
MAZINI 2016
DOI
10.3389/fimmu.2015.00658
Alternate Journal
Front. Immunol.
Publication Language
eng

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