TY - JOUR KW - Mycobacterium leprae KW - Immune response genes KW - Innate immunity KW - leprosy AU - Mazini PS AU - Alves HV AU - Reis ÂG AU - Lopes AP AU - Sell AM AU - Santos-Rosa M AU - Visentainer JEL AU - Rodrigues-Santos P AB -

Leprosy is a chronic infectious disease caused by an obligate intracellular bacterium known as Mycobacterium leprae. Exposure to the bacillus is necessary, but this alone does not mean an individual will develop clinical symptoms of the disease. In recent years, several genes have been associated with leprosy and the innate immune response pathways converge on the main hypothesis that genes are involved in the susceptibility for the disease in two distinct steps: for leprosy per se and in the development of the different clinical forms. These genes participate in the sensing, main metabolic pathway of immune response activation and, subsequently, on the evolution of the disease into its clinical forms. The aim of this review is to highlight the role of innate immune response in the context of leprosy, stressing their participation in the signaling and targeting processes in response to bacillus infection and on the evolution to the clinical forms of the disease.

 

 

 

BT - Frontiers in Immunology C1 -

http://www.ncbi.nlm.nih.gov/pubmed/26793196

CN - MAZINI 2016 DO - 10.3389/fimmu.2015.00658 J2 - Front. Immunol. LA - eng N2 -

Leprosy is a chronic infectious disease caused by an obligate intracellular bacterium known as Mycobacterium leprae. Exposure to the bacillus is necessary, but this alone does not mean an individual will develop clinical symptoms of the disease. In recent years, several genes have been associated with leprosy and the innate immune response pathways converge on the main hypothesis that genes are involved in the susceptibility for the disease in two distinct steps: for leprosy per se and in the development of the different clinical forms. These genes participate in the sensing, main metabolic pathway of immune response activation and, subsequently, on the evolution of the disease into its clinical forms. The aim of this review is to highlight the role of innate immune response in the context of leprosy, stressing their participation in the signaling and targeting processes in response to bacillus infection and on the evolution to the clinical forms of the disease.

 

 

 

PY - 2016 T2 - Frontiers in Immunology TI - Gene Association with Leprosy: A Review of Published Data UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709443/pdf/fimmu-06-00658.pdf ER -