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Effectiveness of Bacillus Calmette Guerin (BCG) vaccination in the prevention of childhood pulmonary tuberculosis: a case control study in Nagpur, India.

Abstract

A hospital-based, pair matched, case control study was carried out to estimate the effectiveness of BCG vaccination in the prevention of childhood pulmonary tuberculosis. The study included 126 incident cases of pulmonary tuberculosis (diagnosed by WHO criteria) below/equal the age of 12 years. Each case was pair matched with one control for age, sex, socio-economic status. Controls were selected from subjects attending study hospital for conditions other than tuberculosis and leprosy. The significant protective association between BCG and childhood pulmonary tuberculosis was observed (OR = 0.39, 95% CI = 0.22, 0.68). The overall vaccine effectiveness was 61% (95% CI = 32%, 78%). BCG was nonsignificantly more effective in underfives, among males and in upper-middle socioeconomic strata. The overall prevented fraction was estimated to be 47.53% (95% CI = 21.41%, 67.25%). Results of this study thus demonstrated a moderate effectiveness of BCG vaccination in prevention of childhood pulmonary tuberculosis in a Central India population.

More information

Type
Journal Article
Author
Zodpey S P
Shrikhande S N
Maldhure B R
Vasudeo N D
Kulkarni S W
Year of Publication
1998
Journal
The Southeast Asian journal of tropical medicine and public health
Volume
29
Issue
2
Number of Pages
285-8
Date Published
1998 Jun
Language
eng
ISSN Number
0125-1562
Alternate Journal
Southeast Asian J. Trop. Med. Public Health
Publication Language
eng