02105nas a2200385   4500000000100000008004100001260001300042653001600055653001600071653002500087653001000112653002100122653002500143653001100168653001100179653001000190653001100200653000900211653001500220653001500235653001600250653002600266653002800292100001500320700001900335700001700354700001600371700001700387245015800404856006700562300001000629490000700639520105900646022001401705       1998                            d  c1998 Jun10aAge Factors10aBCG Vaccine10aCase-Control Studies10aChild10aChild, Preschool10aConfidence Intervals10aFemale10aHumans10aIndia10aInfant10aMale10aOdds Ratio10aPrevalence10aSex Factors10aSocioeconomic Factors10aTuberculosis, Pulmonary1 aZodpey S P1 aShrikhande S N1 aMaldhure B R1 aVasudeo N D1 aKulkarni S W00aEffectiveness of Bacillus Calmette Guerin (BCG) vaccination in the prevention of childhood pulmonary tuberculosis: a case control study in Nagpur, India.  uhttp://www.tm.mahidol.ac.th/seameo/1998-29-2/1998-29-2-285.pdf  a285-80 v293 a<p>A hospital-based, pair matched, case control study was carried out to estimate the effectiveness of BCG vaccination in the prevention of childhood pulmonary tuberculosis. The study included 126 incident cases of pulmonary tuberculosis (diagnosed by WHO criteria) below/equal the age of 12 years. Each case was pair matched with one control for age, sex, socio-economic status. Controls were selected from subjects attending study hospital for conditions other than tuberculosis and leprosy. The significant protective association between BCG and childhood pulmonary tuberculosis was observed (OR = 0.39, 95% CI = 0.22, 0.68). The overall vaccine effectiveness was 61% (95% CI = 32%, 78%). BCG was nonsignificantly more effective in underfives, among males and in upper-middle socioeconomic strata. The overall prevented fraction was estimated to be 47.53% (95% CI = 21.41%, 67.25%). Results of this study thus demonstrated a moderate effectiveness of BCG vaccination in prevention of childhood pulmonary tuberculosis in a Central India population.</p>  a0125-1562