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Effect of thalidomide on the expression of TNF-alpha m-RNA and synthesis of TNF-alpha in cells from leprosy patients with reversal reaction.

Abstract

Hypersensitivity reactions called reversal reaction (RR) and erythema nodosum leprosum (ENL) occur in leprosy. They are characterized by an increase in tumor necrosis factor-alpha (TNF-alpha). Thalidomide is an effective treatment for ENL but not RR. Its effectiveness in ENL is attributed to inhibition of TNF-alpha, and this does not explain its failure to treat RR. We assessed thalidomide's effect on TNF-alpha in RR. Mononuclear cells from RR and non-RR patients and healthy individuals were treated with thalidomide and M.leprae (AFB), a cytosol fraction of M. leprae or Dharmendra lepromin. Thalidomide suppressed TNF-alpha, but when some RR patients' cells were stimulated with AFB, it enhanced TNF-alpha.

More information

Type
Journal Article
Author
Tadesse A
Abebe M
Bizuneh E
Mulugeta W
Aseffa A
Shannon E J
Year of Publication
2006
Journal
Immunopharmacology and immunotoxicology
Volume
28
Issue
3
Number of Pages
431-41
Date Published
2006
Language
eng
ISSN Number
0892-3973
DOI
10.1080/08923970600928023
Alternate Journal
Immunopharmacol Immunotoxicol
Publication Language
eng