TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Antigens, Bacterial
KW - Cell Proliferation
KW - Cell Survival
KW - Cells, Cultured
KW - Erythema Nodosum
KW - Female
KW - Humans
KW - Lepromin
KW - leprosy
KW - Leukocytes, Mononuclear
KW - Lymphocyte Activation
KW - Male
KW - Middle Aged
KW - Mycobacterium leprae
KW - Phytohemagglutinins
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - RNA, Messenger
KW - Thalidomide
KW - Tumor Necrosis Factor-alpha
AU - Tadesse A
AU - Abebe M
AU - Bizuneh E
AU - Mulugeta W
AU - Aseffa A
AU - Shannon E J
AB - <p>Hypersensitivity reactions called reversal reaction (RR) and erythema nodosum leprosum (ENL) occur in leprosy. They are characterized by an increase in tumor necrosis factor-alpha (TNF-alpha). Thalidomide is an effective treatment for ENL but not RR. Its effectiveness in ENL is attributed to inhibition of TNF-alpha, and this does not explain its failure to treat RR. We assessed thalidomide's effect on TNF-alpha in RR. Mononuclear cells from RR and non-RR patients and healthy individuals were treated with thalidomide and M.leprae (AFB), a cytosol fraction of M. leprae or Dharmendra lepromin. Thalidomide suppressed TNF-alpha, but when some RR patients' cells were stimulated with AFB, it enhanced TNF-alpha.</p>
BT - Immunopharmacology and immunotoxicology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/16997792?dopt=Abstract
DA - 2006
DO - 10.1080/08923970600928023	
IS - 3
J2 - Immunopharmacol Immunotoxicol
LA - eng
N2 - <p>Hypersensitivity reactions called reversal reaction (RR) and erythema nodosum leprosum (ENL) occur in leprosy. They are characterized by an increase in tumor necrosis factor-alpha (TNF-alpha). Thalidomide is an effective treatment for ENL but not RR. Its effectiveness in ENL is attributed to inhibition of TNF-alpha, and this does not explain its failure to treat RR. We assessed thalidomide's effect on TNF-alpha in RR. Mononuclear cells from RR and non-RR patients and healthy individuals were treated with thalidomide and M.leprae (AFB), a cytosol fraction of M. leprae or Dharmendra lepromin. Thalidomide suppressed TNF-alpha, but when some RR patients' cells were stimulated with AFB, it enhanced TNF-alpha.</p>
PY - 2006
SP - 431
EP - 41
T2 - Immunopharmacology and immunotoxicology
TI - Effect of thalidomide on the expression of TNF-alpha m-RNA and synthesis of TNF-alpha in cells from leprosy patients with reversal reaction.
VL - 28
SN - 0892-3973
ER -