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Effect of Antioxidant Co-supplementation on Oxidative Stress in Leprosy: A Randomized Open Labelled Hospital Based Study
Biochemical damage produced by reactive oxygen species (ROS) has emerged as an important mechanism influencing the pathogenesis of various diseases including leprosy. Oxidative stress increases in leprosy and studies have advocated use of antioxidants in leprosy treatment. This study examines the effect of coadministration of exogenous antioxidants on various oxidative stress parameters in patients having leprosy. This is an open labelled prospective randomized hospital based study to evaluate the effect of antioxidant supplementation on various oxidative stress parameters in patients having leprosy. Total 65 patients of leprosy were randomized to 2 groups. Group A (intervention group) was given exogenous antioxidants along with MDT whereas Group B (controls) received only MDT. Various oxidative parameters were recorded at baseline and at an end point of 3 months' time period. 40 patients completed the study, 20 in each group. There were statistically significant differences between the two study groups for the total oxidant status and oxidative stress index at the study end point of 3 months. A statistically significant decrease in serum Total oxidant status (TOS) and oxidative stress index(OSI) was seen when non-enzymatic antioxidants were coadministered for 3 months along with standard MDT in patients of leprosy.
Year of Publication
Indian journal of leprosy
Number of Pages