01913nas a2200193   4500000000100000008004100001653002100042100001100063700001500074700001300089700001500102700001500117700001400132245012500146856007700271300001200348490000700360520135200367       2020                            d10aOxidative Stress1 aRaka I1 aGahalaut P1 aMishra N1 aRastogi MK1 aVarshney A1 aAgarwal N00aEffect of Antioxidant Co-supplementation on Oxidative Stress in Leprosy: A Randomized Open Labelled Hospital Based Study  uhttp://www.ijl.org.in/2020/07%20I%20Raka%20et%20al%20191-198%20final.pdf  a191-1980 v923 aBiochemical damage produced by reactive oxygen species (ROS) has emerged as an important mechanism
influencing the pathogenesis of various diseases including leprosy. Oxidative stress increases in leprosy and
studies have advocated use of antioxidants in leprosy treatment. This study examines the effect of coadministration of exogenous antioxidants on various oxidative stress parameters in patients having leprosy.
This is an open labelled prospective randomized hospital based study to evaluate the effect of antioxidant
supplementation on various oxidative stress parameters in patients having leprosy. Total 65 patients of
leprosy were randomized to 2 groups. Group A (intervention group) was given exogenous antioxidants along
with MDT whereas Group B (controls) received only MDT. Various oxidative parameters were recorded at
baseline and at an end point of 3 months' time period. 40 patients completed the study, 20 in each group.
There were statistically significant differences between the two study groups for the total oxidant status and
oxidative stress index at the study end point of 3 months. A statistically significant decrease in serum Total
oxidant status (TOS) and oxidative stress index(OSI) was seen when non-enzymatic antioxidants were coadministered for 3 months along with standard MDT in patients of leprosy.