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Publication

Bactericidal activities of HMR 3647, moxifloxacin, and rifapentine against Mycobacterium leprae in mice.

Abstract

Bactericidal activities of HMR 3647 (HMR), moxifloxacin (MXFX), and rifapentine (RPT) against Mycobacterium leprae, measured by the proportional bactericidal technique in the mouse footpad system, were compared with those of the established antileprosy drugs clarithromycin (CLARI), ofloxacin (OFLO), and rifampin (RMP). Administered in five daily doses of 100 mg/kg of body weight, HMR appeared slightly more bactericidal than CLARI. In a single dose, MXFX at 150 mg/kg was more active than the same dose of OFLO and displayed exactly the same level of activity as RMP at 10 mg/kg; the combination MXFX-minocycline (MINO) (MM) was more bactericidal than the combination OFLO-MINO (OM); RPT at 10 mg/kg was more bactericidal than the same dose of RMP and even more active than the combination RMP-OFLO-MINO (ROM); the combination RPT-MXFX-MINO (PMM) killed 99.9% of viable M. leprae and was slightly more bactericidal than RPT alone, indicating that the combination PMM showed an additive effect against M. leprae.

More information

Type
Journal Article
Author
Consigny S
Bentoucha A
Bonnafous P
Grosset J
Ji B
Year of Publication
2000
Journal
Antimicrobial agents and chemotherapy
Volume
44
Issue
10
Number of Pages
2919-21
Date Published
2000 Oct
Language
eng
ISSN Number
0066-4804
Call Number
CONSIGNY 2000
DOI
10.1128/aac.44.10.2919-2921.2000
Alternate Journal
Antimicrob. Agents Chemother.
Publication Language
eng