02111nas a2200421   4500000000100000008004100001260001300042653001200055653002600067653002600093653001800119653001100137653002100148653000900169653001400178653002300192653001200215653001500227653000900242653003200251653001700283653002500300653001500325653001300340653000900353100001500362700001600377700001600393700001400409700000900423245010900432856007100541300001200612490000700624050001800631520102600649022001401675       2000                            d  c2000 Oct10aAnimals10aAnti-Bacterial Agents10aAnti-Infective Agents10aAza Compounds10aFemale10aFluoroquinolones10aFoot10aKetolides10aLeprostatic Agents10aleprosy10aMacrolides10aMice10aMicrobial Sensitivity Tests10aMoxifloxacin10aMycobacterium leprae10aQuinolines10aRifampin10aSkin1 aConsigny S1 aBentoucha A1 aBonnafous P1 aGrosset J1 aJi B00aBactericidal activities of HMR 3647, moxifloxacin, and rifapentine against Mycobacterium leprae in mice.  uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC90182/pdf/ac002919.pdf  a2919-210 v44  aCONSIGNY 20003 a<p>Bactericidal activities of HMR 3647 (HMR), moxifloxacin (MXFX), and rifapentine (RPT) against Mycobacterium leprae, measured by the proportional bactericidal technique in the mouse footpad system, were compared with those of the established antileprosy drugs clarithromycin (CLARI), ofloxacin (OFLO), and rifampin (RMP). Administered in five daily doses of 100 mg/kg of body weight, HMR appeared slightly more bactericidal than CLARI. In a single dose, MXFX at 150 mg/kg was more active than the same dose of OFLO and displayed exactly the same level of activity as RMP at 10 mg/kg; the combination MXFX-minocycline (MINO) (MM) was more bactericidal than the combination OFLO-MINO (OM); RPT at 10 mg/kg was more bactericidal than the same dose of RMP and even more active than the combination RMP-OFLO-MINO (ROM); the combination RPT-MXFX-MINO (PMM) killed 99.9% of viable M. leprae and was slightly more bactericidal than RPT alone, indicating that the combination PMM showed an additive effect against M. leprae.</p>  a0066-4804