|Title||Vaccination against leprosy at Ben San Leprosy Centre, Ho Chi Minh City, Vietnam.|
|Publication Type||Journal Article|
|Authors||Truoc LV, Ly HM, Thuy NK, Trach DD, Stanford CA, Stanford JL|
|Year of Publication||2001|
|Keywords||Adolescent, Adult, Bacterial Vaccines, BCG Vaccine, Child, Child, Preschool, Female, Humans, Immunization Schedule, Leprosy, Male, Mycobacterium, Skin Tests, Time Factors, Vaccines, Inactivated, Vietnam|
Three vaccines, BCG alone, BCG + 10(7) killed Mycobacterium vaccae and 10(8) killed M. vaccae alone, were studied in children living in close contact with leprosy. In the year before vaccination, 14/446 (3.1%) children had developed leprosy. Among those who were not vaccinated, 9/74 (12.2%) developed the disease in the first 4 years of the study and 5/65 (7.7%) developed the disease in the second 4 years. In comparison with this, among those vaccinated, 20/343 (5.8%) developed leprosy in the first 4 years and 5/323 (1.5%) developed leprosy in the second 4 years. This represents 52.5% protection in the first 4 years and 80.5% in the second 4 years. There were no significant differences in protection afforded by each of the three vaccines but the success of the killed preparation of M. vaccae is an important finding.