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Unusual Presentation of Feline Leprosy Caused by Mycobacterium lepraemurium in the Alpine Region

Abstract
A 9-year-old cat was referred with multiple, raised, ulcerative and non-ulcerative nodules in the periocular area, sclera and ear-base region, and on the ventral aspect of the tongue. In addition, a progressive ulcerative skin nodule on the tail was observed. Fine-needle aspirations of multiple nodules from the eyelid and sclera revealed the presence of histiocytes with numerous acid-fast intracellular bacilli. The replication of slowly growing mycobacteria in liquid media was detected from biopsied nodules after three months of incubation. The molecular characterization of the isolate identified Mycobacterium (M.) lepraemurium as the cause of the infection. The cat was treated with a combination of surgical excision and a four-week course of antimicrobial therapy including rifampicin combined with clarithromycin. This is an unusual manifestation of feline leprosy and the first molecularly confirmed M. lepraemurium infection in a cat with ocular involvement in Europe. The successful combination of a surgical and antimycobacterial treatment regimen is reported.

More information

Type
Journal Article
Author
Ghielmetti G
Schmitt S
Friedel U
Guscetti F
Walser-Reinhardt L
Year of Publication
2021
Journal
Pathogens
Volume
10
Issue
6
Number of Pages
687
Language
eng
ISSN Number
2076-0817
DOI
10.3390/pathogens10060687
Publication Language
eng