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A unique case of borderline lepromatous leprosy presenting with both hypopigmented and hyperpigmented macules

Abstract

Primary hyperpigmentation is rare in leprosy. We report a patient with borderline lepromatous (BL) leprosy who presented with both hypopigmented and hyperpigmented macules. Histopathology with Masson Fontana staining and immunohistochemistry with HMB 45 revealed decreased melanin granules in keratinocytes of basal and superficial layers in hypopigmented macules when compared to hyperpigmented macules. It appears that hypopigmentation in leprosy lesions may be due to defective transfer of melanin into keratinocytes.

More information

Type
Journal Article
Author
Abideen F
Balakrishnan S
Sindhu CB
George S
Sanker A