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Publication

Spatial distribution of leprosy in India: an ecological study.

Abstract

BACKGROUND: As leprosy elimination becomes an increasingly realistic goal, it is essential to determine the factors that contribute to its persistence. We evaluate social and economic factors as predictors of leprosy annual new case detection rates within India, where the majority of leprosy cases occur.

METHODS: We used correlation and linear mixed effect regressions to assess whether poverty, illiteracy, nighttime satellite radiance (an index of development), and other covariates can explain district-wise annual new case detection rate and Grade 2 disability diagnoses.

RESULTS: We find only weak evidence of an association between poverty and annual new case detection rates at the district level, though illiteracy and satellite radiance are statistically significant predictors of leprosy at the district level. We find no evidence of rapid decline over the period 2008-2015 in either new case detection or new Grade 2 disability.

CONCLUSIONS: Our findings suggest a somewhat higher rate of leprosy detection, on average, in poorer districts; the overall effect is weak. The divide between leprosy case detection and true incidence of clinical leprosy complicates these results, particularly given that the detection rate is likely disproportionately lower in impoverished settings. Additional information is needed to distinguish the determinants of leprosy case detection and transmission during the elimination epoch.

More information

Type
Journal Article
Author
Grantz KH
Chabaari W
Samuel RK
Gershom B
Blum L
Worden L
Ackley S
Liu F
Lietman TM
Galvani AP
Prajna L
Porco TC
Year of Publication
2018
Journal
Infectious diseases of poverty
Volume
7
Issue
1
Number of Pages
20
Language
eng
ISSN Number
2049-9957
DOI
10.1186/s40249-018-0402-y
Alternate Journal
Infect Dis Poverty
Publication Language
eng