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Publication

Severe adverse reactions to multidrug therapy for leprosy, registered in tertiary services between 2012 and 2017 in Brazil

Abstract

Objectives: This work aims to determinate the main severe adverse reactions to multidrug therapy (MDT), as well as the characteristics of the patients who had them and the period when they were more prevalent.
Results: Of the 158 patients undergoing treatment for leprosy in the period 2012–2017, 22 (13·9%) were using substitutive treatment for leprosy and presented criteria to enter this study. Adverse reactions were more frequent in women (59·1%), above 45 years age and during second month of treatment. Dapsone was the most frequently implied drug (86·4%), and hemolytic anemia was the main reaction (72·7%).
Conclusion: Severe adverse reaction to dapsone is common in MDT, mainly due to hemolytic anemia.

More information

Type
Journal Article
Author
Pante CC
Coelho SC
Carelli L
Avancini J
Trindade MAB
Year of Publication
2018
Journal
Leprosy review
Volume
89
Issue
4
Number of Pages
328-334
Language
eng
Alternate Journal
Lepr Rev
Publication Language
eng