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Publication

The secret lives of the pathogenic mycobacteria.

Abstract

Pathogenic mycobacteria, including the causative agents of tuberculosis and leprosy, are responsible for considerable morbidity and mortality worldwide. A hallmark of these pathogens is their tendency to establish chronic infections that produce similar pathologies in a variety of hosts. During infection, mycobacteria reside in macrophages and induce the formation of granulomas, organized immune complexes of differentiated macrophages, lymphocytes, and other cells. This review summarizes our understanding of Mycobacterium-host cell interactions, the bacterial-granuloma interface, and mechanisms of bacterial virulence and persistence. In addition, we highlight current controversies and unanswered questions in these areas.

More information

Type
Journal Article
Author
Cosma CL
Sherman DR
Ramakrishnan L
Year of Publication
2003
Journal
Annual review of microbiology
Volume
57
Number of Pages
641-76
Date Published
2003
Language
eng
ISSN Number
0066-4227
DOI
10.1146/annurev.micro.57.030502.091033
Alternate Journal
Annu. Rev. Microbiol.
Publication Language
eng