Role of HLA, KIR, MICA, and cytokines genes in leprosy.

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TitleRole of HLA, KIR, MICA, and cytokines genes in leprosy.
Publication TypeJournal Article
AuthorsJarduli LR, Sell AM, Reis PG, Sippert EÂ, Ayo CM, Mazini PS, Alves HV, Teixeira JJV, Visentainer JEL
Abbrev. JournalBiomed Res Int
JournalBioMed research international
Year of Publication2013
Publication Languageeng
KeywordsAlleles, Cytokines, Genetic Predisposition to Disease, Genome-Wide Association Study, Histocompatibility Antigens Class I, HLA Antigens, Humans, Killer Cells, Natural, Leprosy, Receptors, KIR

Many genes including HLA, KIR, and MICA genes, as well as polymorphisms in cytokines have been investigated for their role in infectious disease. HLA alleles may influence not only susceptibility or resistance to leprosy, but also the course of the disease. Some combinations of HLA and KIR may result in negative as well as positive interactions between NK cells and infected host cells with M. leprae, resulting in activation or inhibition of NK cells and, consequently, in death of bacillus. In addition, studies have demonstrated the influence of MICA genes in the pathogenesis of leprosy. Specifically, they may play a role in the interaction between NK cells and infected cells. Finally, pro- and anti-inflammatory cytokines have been influencing the clinical course of leprosy. Data from a wide variety of sources support the existence of genetic factors influencing the leprosy pathogenesis. These sources include twin studies, segregation analyses, family-based linkage and association studies, candidate gene association studies, and, most recently, genome-wide association studies (GWAS). The purpose of this brief review was to highlight the importance of some immune response genes and their correlation with the clinical forms of leprosy, as well as their implications for disease resistance and susceptibility.

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Shelf markJARDULI 2013
PubMed Central IDPMC3722889