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Publication

Role of HLA, KIR, MICA, and cytokines genes in leprosy.

Abstract

Many genes including HLA, KIR, and MICA genes, as well as polymorphisms in cytokines have been investigated for their role in infectious disease. HLA alleles may influence not only susceptibility or resistance to leprosy, but also the course of the disease. Some combinations of HLA and KIR may result in negative as well as positive interactions between NK cells and infected host cells with M. leprae, resulting in activation or inhibition of NK cells and, consequently, in death of bacillus. In addition, studies have demonstrated the influence of MICA genes in the pathogenesis of leprosy. Specifically, they may play a role in the interaction between NK cells and infected cells. Finally, pro- and anti-inflammatory cytokines have been influencing the clinical course of leprosy. Data from a wide variety of sources support the existence of genetic factors influencing the leprosy pathogenesis. These sources include twin studies, segregation analyses, family-based linkage and association studies, candidate gene association studies, and, most recently, genome-wide association studies (GWAS). The purpose of this brief review was to highlight the importance of some immune response genes and their correlation with the clinical forms of leprosy, as well as their implications for disease resistance and susceptibility.

More information

Type
Journal Article
Author
Jarduli LR
Sell AM
Reis PG
Sippert EÂ
Ayo CM
Mazini PS
Alves HV
Teixeira JJV
Visentainer JEL
Year of Publication
2013
Journal
BioMed research international
Volume
2013
Number of Pages
989837
Date Published
2013
Language
eng
ISSN Number
2314-6141
Call Number
JARDULI 2013
DOI
10.1155/2013/989837
Alternate Journal
Biomed Res Int
Publication Language
eng