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Quantitative analyses and modelling to support achievement of the 2020 goals for nine neglected tropical diseases.

Abstract

Quantitative analysis and mathematical models are useful tools in informing strategies to control or eliminate disease. Currently, there is an urgent need to develop these tools to inform policy to achieve the 2020 goals for neglected tropical diseases (NTDs). In this paper we give an overview of a collection of novel model-based analyses which aim to address key questions on the dynamics of transmission and control of nine NTDs: Chagas disease, visceral leishmaniasis, human African trypanosomiasis, leprosy, soil-transmitted helminths, schistosomiasis, lymphatic filariasis, onchocerciasis and trachoma. Several common themes resonate throughout these analyses, including: the importance of epidemiological setting on the success of interventions; targeting groups who are at highest risk of infection or re-infection; and reaching populations who are not accessing interventions and may act as a reservoir for infection,. The results also highlight the challenge of maintaining elimination 'as a public health problem' when true elimination is not reached. The models elucidate the factors that may be contributing most to persistence of disease and discuss the requirements for eventually achieving true elimination, if that is possible. Overall this collection presents new analyses to inform current control initiatives. These papers form a base from which further development of the models and more rigorous validation against a variety of datasets can help to give more detailed advice. At the moment, the models' predictions are being considered as the world prepares for a final push towards control or elimination of neglected tropical diseases by 2020.

More information

Type
Journal Article
Author
Hollingsworth DT
Adams ER
Anderson RM
Atkins K
Bartsch S
Basáñez M
Behrend M
Blok DJ
Chapman LA C
Coffeng L
Courtenay O
Crump RE
Vlas SJ
Dobson A
Dyson L
Farkas H
Galvani AP
Gambhir M
Gurarie D
Irvine MA
Jervis S
Keeling MJ
Kelly-Hope LA
King C
Lee BY
Le Rutte EA
Lietman TM
Ndeffo-Mbah M
Medley GF
Michael E
Pandey A
Peterson JK
Pinsent A
Porco TC
Richardus JH
Reimer L
Rock KS
Singh BK
Stolk W
Swaminathan S
Torr SJ
Townsend J
Truscott J
Walker M
Zoueva A
Year of Publication
2015
Journal
Parasites & vectors
Volume
8
Issue
1
Number of Pages
630
Language
eng
ISSN Number
1756-3305
DOI
10.1186/s13071-015-1235-1
Alternate Journal
Parasit Vectors
Publication Language
eng