Pustular type 2 reaction of lepromatous leprosy with presence of antiphospholipid antibodies: A case report and literature review

Lepra reactions are the immune reactions of leprosy. They can be divided into type 1, type 2 [erythema nodosum leprosy (ENL)], and type 3 reactions (Lucio phenomenon). The typical clinical characteristics of ENL are crops of tender and erythematous papuloplaques accompanied by constitutional symptoms. Here, we reported a case of ENL with generalized eruptions studded with pustules that was misdiagnosed as antiphospholipid syndrome (APS) due to the presence of immunoglobulin (Ig)M isotypes of antiphospholipid (aPl) antibodies.