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Protective effect of the combination BCG vaccination and rifampicin prophylaxis in leprosy prevention.

Abstract

BCG vaccination and rifampicin chemoprophylaxis are both strategies for leprosy prevention. While the combined effect is unknown, the combination may give the desired push to halt leprosy transmission. Secondary analysis was done on results from a single centre, double blind, cluster randomized, and placebo-controlled trial. Individually, BCG (given at infancy) and rifampicin showed to protect against leprosy (57% [95% CI: 24-75%] and 58% [95% CI: 30-74%], respectively). The combined strategies showed a protective effect of 80% (95% CI: 50-92%). This is the first time that the additive effect of BCG and rifampicin are shown; the combined strategies can possibly lower leprosy incidence.

More information

Type
Journal Article
Author
Schuring RP
Richardus JH
Pahan D
Oskam L
Year of Publication
2009
Journal
Vaccine
Volume
27
Issue
50
Number of Pages
7125-8
Date Published
2009 Nov 23
Language
eng
ISSN Number
1873-2518
DOI
10.1016/j.vaccine.2009.09.054
Alternate Journal
Vaccine
Publication Language
eng