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Publication

Prospective study of serological conversion as a risk factor for development of leprosy among household contacts.

Abstract

Although the prevalence of leprosy has declined over the years, there is no evidence that incidence rates are falling. A method of early detection of those people prone to develop the most infectious form of leprosy would contribute to breaking the chain of transmission. Prophylactic treatment of serologically identified high-risk contacts of incident patients should be an operationally feasible approach for routine control programs. In addition, classification of high-risk household contacts will allow control program resources to be more focused. In this prospective study, we examined the ability of serology used for the detection of antibodies to phenolic glycolipid I of Mycobacterium leprae to identify those household contacts of multibacillary leprosy patients who had the highest risk of developing leprosy. After the start of multidrug therapy for the index case, a new case of leprosy developed in one in seven of the 178 households studied. In households where new cases appeared, the seropositivity rates were significantly higher (P < 0.001) than those in households without new cases. Seropositive household contacts had a significantly higher risk of developing leprosy (relative hazard adjusted for age and sex [aRH], 7.2), notably multibacillary leprosy (aRH = 24), than seronegative contacts.

More information

Type
Journal Article
Author
Douglas J T
Cellona R V
Fajardo T T
Abalos R M
Balagon M V F
Klatser P R
Year of Publication
2004
Journal
Clinical and diagnostic laboratory immunology
Volume
11
Issue
5
Number of Pages
897-900
Date Published
2004 Sep
Language
eng
ISSN Number
1071-412X
DOI
10.1128/CDLI.11.5.897-900.2004
Alternate Journal
Clin. Diagn. Lab. Immunol.
Publication Language
eng