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Publication

Prevention of leprosy using rifampicin as chemoprophylaxis.

Abstract

An intervention study was implemented on five Indonesian islands highly endemic for leprosy to determine whether rifampicin can be used as chemoprophylaxis to prevent leprosy. The population was actively screened before the intervention and subsequently once a year for three years. In the control group, no chemoprophylaxis was given. In the contact group, chemoprophylaxis was only given to contacts of leprosy patients and in the blanket group to all eligible persons. The cohort consisted of 3,965 persons. The yearly incidence rate in the control group was 39/10,000; the cumulative incidence after three years was significantly lower in the blanket group (P = 0.031). No difference was found between the contact and the control groups (P = 0.93). Whether this apparent reduced leprosy incidence in the first three years in the blanket group is due to a delayed development of leprosy or a complete clearance of infection needs to be determined.

More information

Type
Journal Article
Author
Bakker MI
Hatta M
Kwenang A
Van Benthem BH B
Beers SM
Klatser PR
Oskam L
Year of Publication
2005
Journal
The American journal of tropical medicine and hygiene
Volume
72
Issue
4
Number of Pages
443-8
Date Published
2005 Apr
Language
eng
ISSN Number
0002-9637
Call Number
BAKKER 2005
Alternate Journal
Am. J. Trop. Med. Hyg.
Publication Language
eng