Painful bullae in a febrile woman: a clue to first presentation of multibacillary Hansen's disease.

A woman in her 40s presented to the emergency department with 8 days of fever and malaise. Along with the fever, crops of multiple painful reddish raised lesions appeared for the first time on the face, upper limbs and trunk. There was no history of loss of sensation or weakness of the extremities. No significant history of systemic complaint was present. She received only symptomatic management for these complaints from a general physician with no improvement of the lesions. On examination, she was febrile with a temperature of 38.5°C, heart rate of 104 beats per minute and blood pressure of 104/60 mm Hg. Multiple, tender, oedematous and erythematous plaques, few of which with central flaccid to tense bullae containing clear to turbid were distributed on forehead, trunk and extremities (figure 1A,B). There were no other significant findings including other skin lesions like hypoaesthetic or anaesthetic macules or plaques were not evident clinically. Palpation of peripheral nerves, sensory and motor examinations were within normal limits with no hand and feet deformity. Laboratory tests revealed mildly raised leucocytosis, neutrophilia (92%) and elevated inflammatory markers (procalcitonin of 3 ng/mL and C reactive protein of 14 mg/L). Due to the characteristic cutaneous lesions, skin punch biopsy for histopathological examination was done from a fresh erythematous nodule on the left forearm with a suspicion of Sweet’s syndrome (SS) with its bullous variant, which revealed diffuse and intense dermal oedema with separated collagen, diffuse foamy histiocyte aggregates with periadnexal accentuation of lymphohistiocytic collections (figure 2A, H&E and 4×). Furthermore, Fite Faraco stain was done on skin biopsy section which showed several globi of lepra bacilli distributed mainly around the hair follicles and dermal blood vessels suggestive of erythema nodosum leprosum with Fite stain showing multiple globi of lepra bacilli (figure 2B). MB-MDT (multibacillary-multidrug therapy), prednisolone 40 mg, non-steroidal anti-inflammatory drugs were started with improvement of the lesions after 2 weeks of follow-up.