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NINJURIN1 single nucleotide polymorphism and nerve damage in leprosy.

Abstract

UNLABELLED: Leprosy, a chronic infectious disease caused by Mycobacterium leprae, can damage the peripheral nervous system and represents one of the leading causes of nontraumatic neuropathy in some developing countries. The NINJURIN1 is a cell adhesion molecule that provides suitable substrates for repair of Schwann cells after peripheral nerve injury. The single nucleotide polymorphism NINJ1, is the result of a transversion of an adenine to a nucleotide polymorphic cytokine (A→C), responsible for an amino acid exchange of asparagine to alanine at position 110 of the protein (asp110ala).

OBJECTIVES: The aim of this study was to investigate the importance of the polymorphism in the NINJ1 gene for neural impairment during leprosy course.

METHODS: A single nucleotide polymorphism (asp110ala) was searched in 218 leprosy patients and 244 non-leprosy subjects using a polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) method.

RESULTS: No statistical differences were observed in the frequency of the asp110ala SNP between leprosy patients versus non-leprosy and multibacillary versus paucibacillary clinical forms. The C allele (ala110) is increased among patients exhibiting nerve impairment (p=0.0379). Also, leprosy patients with the CC genotype (ala/ala) had a higher risk (OR=4.21) of developing nerve disability when compared those carrying the AA genotype (asp/asp) (OR=0.69).

CONCLUSION: Our results show an association between the studied C allele (ala110) and damage nerve in leprosy patients.

SIGNIFICANCE: Ninjurin analysis showed that asp110ala could be a valuable prognostic marker, since C allele (ala110) have increased susceptibility to nerve damage.

More information

Type
Journal Article
Author
Graça CR
Paschoal VD A
Cordeiro-Soubhia RM
Tonelli-Nardi SM
Machado RL D
Kouyoumdjian JA
Baptista Rossit AR
Country
The Netherlands
Year of Publication
2012
Journal
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Volume
12
Issue
3
Number of Pages
597-600
Date Published
2012 Apr
Language
eng
ISSN Number
1567-7257
DOI
10.1016/j.meegid.2012.01.023
Alternate Journal
Infect. Genet. Evol.
Publication Language
eng