The dividing line between non-communicable and communicable disease is quite blurred. This has been explained through an analogy between neglected tropical diseases (NTDs) and spatial neglect. The electronic databases such as MEDLINE, Tropical Diseases Research Division at the WHO and Google Scholar were consulted and reference lists of articles were searched for relevant material. Spatial neglect is a common complication following stroke. Both NTDs and spatial neglect demonstrate a preference for space and pose challenges in control and management. Although they may appear to be different entities, at least three NTDs (Chagas disease, neurocysticercosis, and schistosomiasis) have been implicated as risk factors for stroke (and thence spatial neglect). This makes NTDs an issue of international concern, unrestricted to the tropics, and too important to be neglected.