Mycobacterium vaccae in immunoprophylaxis and immunotherapy of leprosy and tuberculosis.

Printer-friendly version
TitleMycobacterium vaccae in immunoprophylaxis and immunotherapy of leprosy and tuberculosis.
Publication TypeJournal Article
AuthorsStanford JL, Rook GA, Bahr GM, Dowlati Y, Ganapati R, Ghazi Saidi K, Lucas S, Ramu G, Torres P, Minh Ly H
Abbrev. JournalVaccine
JournalVaccine
Year of Publication1990
Volume8
Issue6
Pagination525-30
Publication Languageeng
KeywordsAnimals, Bacterial Vaccines, Child, Child, Preschool, Humans, Immunotherapy, Leprosy, Mycobacterium, Premedication, Tuberculosis
Abstract

Both leprosy and tuberculosis present continuing problems in their control, especially in the developing world, despite the availability of drugs effective in producing a bacteriological cure. Improved immunoprophylaxis, and an effective immunotherapy to be used with chemotherapy are urgently required. Intradermal injection of a suspension of killed Mycobacterium vaccae promotes cell-mediated responses to antigens common to all mycobacteria, and switches off the tissue-necrotizing aspects of the Koch phenomenon. These properties led to the use of the suspensions as an improved vaccine, either alone or in combination with BCG. The same properties led to the employment of the suspension in immunotherapy as an adjunct to chemotherapy in the treatment of both leprosy and tuberculosis. The evidence leading to these conclusions is reviewed and discussed.

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/2087873?dopt=Abstract

DOI10.1016/0264-410x(90)90002-4

More resources on: