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Publication

Microscopic leprosy skin lesions in primary neuritic leprosy.

Abstract

The histologic diagnosis of primary neuritic leprosy (PNL) remains a public health care concern, especially when nerve biopsies cannot be performed. As such, some authors emphasize the importance of performing a skin biopsy of a hypoesthetic area even without clinically visible lesions. In this study, an attempt was made to define the histologic changes in the sensory altered skin of 42 clinically diagnosed PNL patients. Histologic alterations caused by leprosy were seen in 31% of these patients: 6 were classified as borderline tuberculoid and 7 as indeterminate. In addition, 33% showed mild, non-specific, mononuclear cell infiltrates around the blood vessels within the papillary and reticular dermis that probably reflected an early inflammatory reaction to Mycobacterium leprae infection. Only 36% of those biopsied had no significant lesions. Our results suggested that, while not all PNL patients are similar, histologic skin examination can contribute to early leprosy detection and commencement of adequate treatment.

More information

Type
Journal Article
Author
Menicucci LA
Miranda A
Antunes SLG
Jardim MR
Costa Nery JA
Sales AM
Sarno EN
Year of Publication
2005
Journal
Journal of the American Academy of Dermatology
Volume
52
Issue
4
Number of Pages
648-52
Date Published
2005 Apr
Language
eng
ISSN Number
1097-6787
DOI
10.1016/j.jaad.2004.11.068
Alternate Journal
J. Am. Acad. Dermatol.
Publication Language
eng