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Publication

Micronutrients influencing the immune response in leprosy.

Abstract
Leprosy is a chronic infectious disease caused by Mycobacterium leprae, an intracellular bacillus of airborne transmission. The disease affects the skin and peripheral nerves and can cause neurological sequelae. The bacillus multiplies slowly in the host and the disease probably occurs due to malfunctioning in host immune response. This review addresses the role of some specific micronutrients in the immune response, such as Vitamins A, D, E, C, Zinc and Selenium, detailing their mechanisms of actions in infectious diseases, and in leprosy. The immune response to pathogens releases harmful substances, which lead to tissue damage. This review discusses how a decreased level of antioxidants may contribute to an increased oxidative stress and complications of infectious diseases and leprosy. As the nutrients have a regulatory effect in the innate and adaptative immune responses, a perfect balance in their concentrations is important to improve the immune response against the pathogens.

More information

Type
Journal Article
Author
Passos Vázquez CM
Mendes Netto RS
Ferreira Barbosa KB
Rodrigues de Moura T
De Almeida RP
Duthie MS
Ribeiro de Jesus A
Year of Publication
2014
Journal
Nutrición hospitalaria
Volume
29
Issue
1
Number of Pages
26-36
Date Published
2014 Jan-Feb
Language
eng
ISSN Number
1699-5198
DOI
10.1371/journal.pntd.0002845
Alternate Journal
Nutr Hosp
Publication Language
eng

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