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Lucio's phenomenon: a report of three cases seen in Johor, Malaysia.

Abstract

BACKGROUND: Lucio's phenomenon is a rare and aggressive necrotising variant of erythema nodosum leprosum that classically occur in patients with undiagnosed, diffuse non-nodular lepromatous leprosy. It is a potentially fatal leprosy reaction characterised by extensive, bizarrely-shaped, painful purpuric skin lesions and ulcerations. Lucio's phenomenon is very rarely reported outside of Mexico and Costa Rica.

METHODS: We describe 3 cases seen in Johor, Malaysia.

RESULTS: The first two cases responded to the prompt simultaneous institution of daily rifampicin, dapsone, clofazimine and prednisolone. Case 3 continued to have new lesions and extension of existing lesions while on dapsone and clofazimine. The subsequent addition of rifampicin and prednisolone prevented new lesion formation but patient succumbed to the extensive cutaneous infarcts and consequent sepsis.

CONCLUSIONS: Early diagnosis and prompt institution of multi-drug therapy together with prednisolone may improve the prognosis and outcome of Lucio's phenomenon.

More information

Type
Journal Article
Author
Choon SE
Tey KE
Year of Publication
2009
Journal
International journal of dermatology
Volume
48
Issue
9
Number of Pages
984-8
Date Published
2009 Sep
Language
eng
ISSN Number
1365-4632
DOI
10.1111/j.1365-4632.2009.04078.x
Alternate Journal
Int. J. Dermatol.
Publication Language
eng