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Lesional fine needle aspiration (FNA) cytology in reactional and non-reactional leprosy patients

Abstract
Fine needle aspiration cytology (FNAC) is a relatively simpler tool as compared to histopathology for the evaluation of the cytomorphology of skin lesions. Fifty consecutive leprosy patients diagnosed and classified according to Ridley Jopling scale1 were taken to study the cytomorphology of leprosy lesions in fine needle aspirates and correlate it with their histopathology by a skin biopsy from the same site for histopathological examination after H/E staining. Borderline leprosy patients with Type I reaction showed significantly more numbers of giant cells, collagen and elastin in their smears as compared to those without reaction. The smears were more heavily cellular with fragmented collagen and elastin along with significant increase in neutrophils in patients with Type II reaction while foamy macrophages with fatty background were common in non-reactional lepromatous leprosy patients. A complete correlation between histopathological and cytomorphological findings was observed in 79.4% of cases.

More information

Type
Journal Article
Author
Patel DA
Sethi PN
Year of Publication
2020
Journal
International Journal of Clinical and Diagnostic Pathology
Volume
3
Issue
3
Number of Pages
192-194
Language
eng
ISSN Number
2617-7226, 2617-7234
DOI
10.33545/pathol.2020.v3.i3c.285
Publication Language
eng