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Publication

Lack of cytotoxic activity against Mycobacterium leprae 65-kD heat shock protein (hsp) in multibacillary leprosy patients.

Abstract

Cytotoxic T cells play an important role in host defence mechanisms, as well as in the immunopathology of leprosy. In this study, we evaluated whether Mycobacterium leprae hsp18, hsp65 and Myco. tuberculosis hsp71 could induce cytotoxic T cell activity against autologous macrophages pulsed with these hsp. Paucibacillary (PB) patients and normal controls generated more effector cells than multibacillary (MB) patients with all three hsp tested. There was no cross-reactivity between any of the hsp tested. Mycobacterium leprae hsp65 induced cytotoxic responses only in those MB patients undergoing an erythema nodosum leprosum (ENL) episode. Although hsp65 and hsp18 induced similar proliferation in MB patients, a high proportion of these patients did not generate cytotoxic effector cells in response to hsp65. Hence, those T cells reacting to hsp65 may play an important role in the control of Myco. leprae infection.

More information

Type
Journal Article
Author
De La Barrera S
Fink S
Finiasz M
Minnucci F
Valdez R
Baliña L M
Sasiain M C
Year of Publication
1995
Journal
Clinical and experimental immunology
Volume
99
Issue
1
Number of Pages
90-7
Date Published
1995 Jan
Language
eng
ISSN Number
0009-9104
DOI
10.1111/j.1365-2249.1995.tb03477.x
Alternate Journal
Clin. Exp. Immunol.
Publication Language
eng