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Publication

Kinetic changes of antibody to M. leprae and its relation with clinical disease.

Abstract

A sero-epidemiological survey on 1,833 healthy residents was carried out in 6 villages of a leprosy high-endemic area in Wenshan and Guangnan counties, Yunnan Province. The part of the residents with initially antibody-positive as well as the part of residents with initially antibody-negative have been followed up for 3 consecutive years by serology and clinical examination for studying kinetic changes of antibody to M. leprae and its relation with clinical disease. The results showed that the rates of subclinical infection of leprosy in a high-endemic area are different from village to village, and the risk of developing clinical disease does not associate with subclinical infection rate. It correlates with the number of cured accumulative leprosy cases and active cases within the village. The authors consider that in leprosy high-endemic villages, especially those cropped up new multi-bacillary leprosy cases frequently in recent years, it may be helpful to use serology to detect early leprosy cases.

More information

Type
Journal Article
Author
Jianping S
Wenzhong L
Ganyun Y
Wanhui W
Liangbin Y
Xiangsheng C
Wenbiao H
Fenwu L
Shunpeng R
Year of Publication
1999
Journal
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
Volume
14
Issue
1
Number of Pages
52-6
Date Published
03/1999
Language
eng
ISSN Number
1001-9294
Alternate Journal
Chin Med Sci J
PMID
12899385
Publication Language
eng