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Interleukin-12 and Interleukin-4 Levels of Multibacillary Leprosy Patients Before and After Rifampicine Ofloxacine Minocycline Combined Therapy


Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which is an obligate intracellular bacteria. This study aims to determine the interleukin-12 and interleukin-4 levels of multibacillary leprosy patients before and after Rifampicine Ofloxacine Minocycline (ROM) combined therapy for three months. The research used an analytic observational design with the prospective cohort study pre and post treatment method. The samples were taken at the polyclinic of Skin Treatment Central Public hospital and Ibnu Sina hospital. Samples examination was conducted in the NECHRI laboratory, Hasanuddin University Teaching hospital. The samples were ten new patients of MB type leprosy. Blood samples were taken before and after the ROM therapy for three months. The levels of interleukin-12 and interleukin-4 were assessed using the ELISA technique. The results shows that there is no significant change in the levels of interleukin-12 and interleukin-4 in the patients of multibacillary leprosy before and after ROM therapy for three months.

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Journal Article
Budhiani S
Muchtar SV
Amin S