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Publication

Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil.

Abstract

BACKGROUND: The objective of this study was to investigate the association between KIR genes and the immunopathogenesis of leprosy.

METHODS: The types of KIR and HLA genes were evaluated by PCR-SSOP-Luminex in 408 patients with leprosy and 413 healthy individuals. Statistical analysis was performed using the Chi-square or Fisher's exact test and stepwise multivariate analysis.

RESULTS: There was a higher frequency of activating KIR genes (KIR2DS1, 2DS2 and 3DS1) together with their HLA ligands in the tuberculoid (TT) group as compared to the lepromatous leprosy (LL) group. KIR2DL2/2DL2-C1 was more frequent in the patient, TT and LL groups than in the control group. Borderline patients presented a higher frequency of inhibitory pairs when compared to the control group, and a higher frequency of activating pairs as compared to the LL group. Multivariate analysis confirmed the associations and demonstrated that being a female is a protective factor against the development of the disease per se and the more severe clinical form.

CONCLUSIONS: This study showed that activating and inhibitory KIR genes may influence the development of leprosy - in particular, activating genes may protect against the more aggressive form of the disease - thereby demonstrating the role of NK cells in the immunopathology of the disease.

More information

Type
Journal Article
Author
Jarduli LR
Alves HV
Souza-Santana FC
Marcos EVC
Pereira AC
Dias-Baptista IMF
Fava VM
Mira MT
Moraes MO
Virmond MCL
Visentainer JEL
Year of Publication
2014
Journal
BMC infectious diseases
Volume
14
Issue
1
Number of Pages
438
Language
eng
ISSN Number
1471-2334
DOI
10.1186/1471-2334-14-438
Alternate Journal
BMC Infect. Dis.
Publication Language
eng