Incidence of neuritis among paucibacillary leprosy patients during treatment and surveillance.

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TitleIncidence of neuritis among paucibacillary leprosy patients during treatment and surveillance.
Publication TypeJournal Article
AuthorsJohn AS
Abbrev. JournalIndian J Lepr
JournalIndian journal of leprosy
Year of Publication2004
Volume76
Issue3
Pagination215-22
Publication Languageeng
KeywordsAdult, Clofazimine, Cohort Studies, Drug Therapy, Combination, Female, Humans, Incidence, India, Leprostatic Agents, Leprosy, Male, Peripheral Nervous System Diseases, Pregnancy
Abstract

A cohort study was done on 180 patients receiving the standard WHO PB-MDT regimen at the TLM Hospital in Kolkata, during MDT and 2 years of surveillance to determine the incidence of neuritis. Neuritis occurred in only 2 out of the 180 patients, confirming that the current WHO treatment for PB-MDT is attendant with minimal risk of neuritis. No risk factors were found, except pregnancy in a female patient. While addition of clofazimine in the new U-MDT under trial might take care of the occasional neuritis, further clinical research might be useful to identify sub-groups of PB patients at risk of neuritis.

PubMed URL

http://www.ncbi.nlm.nih.gov/pubmed/15835606?dopt=Abstract

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