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Publication

Immunology of leprosy.

Abstract

Leprosy is a disease caused by (ML) with diverse clinical manifestations, which are strongly correlated with the host's immune response. Skin lesions may be accompanied by peripheral neural damage, leading to sensory and motor losses, as well as deformities of the hands and feet. Both innate and acquired immune responses are involved, but the disease has been classically described along a Th1/Th2 spectrum, where the Th1 pole corresponds to the most limited presentations and the Th2 to the most disseminated ones. We discuss this dichotomy in the light of current knowledge of cytokines, Th subpopulations and regulatory T cells taking part in each leprosy presentation. Leprosy reactions are associated with an increase in inflammatory activity both in limited and disseminated presentations, leading to a worsening of previous symptoms or the development of new symptoms. Despite the efforts of many research groups around the world, there is still no adequate serological test for diagnosis in endemic areas, hindering the eradication of leprosy in these regions.

More information

Type
Journal Article
Author
Froes L
Trindade M
Sotto M
Year of Publication
2020
Journal
International reviews of immunology
Number of Pages
1-21
Date Published
11/2020
Language
eng
ISSN Number
1563-5244
DOI
10.1080/08830185.2020.1851370
Alternate Journal
Int Rev Immunol
PMID
33241709
Publication Language
eng