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Immunohistologic comparison between armadillo-derived leprosin and standard lepromin skin tests in leprosy patients.

Abstract

A comparison was made on the in situ immunological characteristics of dermal infiltrates of early (24-hour) and late (3-4 weeks) skin reactions in leprosy patients. The skin reactions were induced by armadillo-derived leprosin coupled to liposomes and standard Dharmendra lepromin. Most lymphocytes in the early reaction induced by both antigens were positive for Leu 4, Leu 3a, OKT8 and Ia like antigens indicating thereby the presence of activated T cells. The ratio of Leu 3a/OKT8+ cells were similar. In the late reaction elicited by both antigens, the lymphocytes in the granulomas were predominantly activated T lymphocytes expressing Leu 4, Leu 3a, OKT8 and Ia like antigens. Leu 3a+ cells were scattered diffusely amidst the epithelioid cells. In contrast, the OKT8+ cells were present mainly as 'a ring' in the periphery of the granuloma. A similar ratio of Leu 3a+/OKT8+ cells was observed in these granulomas. Macrophages in the granulomas expressed Ia like antigens. These observations indicate that the immunological characteristics of dermal infiltrates in the skin reaction induced by armadillo-derived leprosin coupled to liposomes and standard Dharmendra lepromin appear to be identical.

More information

Type
Journal Article
Author
Narayanan R B
Ramu G
Sinha S
Sengupta U
Gupta C M
Year of Publication
1987
Journal
International archives of allergy and applied immunology
Volume
82
Issue
2
Number of Pages
202-7
Date Published
1987
Language
eng
ISSN Number
0020-5915
DOI
10.1159/000234187
Alternate Journal
Int. Arch. Allergy Appl. Immunol.
Publication Language
eng

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