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Publication

[Genotyping of Mycobacterium leprae in Guangdong province].

Abstract

OBJECTIVE: To understand the genotypes of Mycobacterium leprae collected from Guangdong province, China and to analyze the routes of leprosy transmission both inside and outside of Guangdong. The impact of emigrant leprosy patients to the endemic nature of the disease in Guangdong was also studied.

METHODS: Typing on strains with variable number of tandem repeats (VNTR) and single nucleotide polymorphism (SNP) were performed on the local cases and emigrant cases based on skin biopsy.

RESULTS: Most isolates from local patients belong to SNP type 1 and SNP type 3 isolates were found just in a small part of local isolates. However, all the emigrants were carrying SNP type 3. Within the SNP type 1 strain from Guangdong, alleles at the 18-8, 12-5, ML-1, (TA) 10 and (GGT) 5 differed from SNP 3 strains collected from other areas in China. However, all the SNP type 1 and SNP type 3 local isolates identified from Guangdong were having close VNTR profiles and the main differences appeared in the alleles at ML-1, (TA) 10 and (GGT) 5.

CONCLUSION: The transmission of strain with SNP type 1 seemed to be associated to the "Silk Road on the Sea", calling for monitoring and confirming the transmission of patients with SNP type 3 in Guangdong were from the secondary transmission, by the emigrant patients. Further study on the historic spread and phylogenetic relationships between SNP type 1 and novel SNP type 3 in Guangdong is needed.

More information

Type
Journal Article
Author
Li M
Wang X
Su T
Xing Y
Weng X
Year of Publication
2013
Journal
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Volume
34
Issue
5
Number of Pages
424-7
Date Published
2013 May
Language
chi
ISSN Number
0254-6450
Alternate Journal
Zhonghua Liu Xing Bing Xue Za Zhi
Publication Language
chi