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Genetics of susceptibility to leprosy.

Abstract

The ancient disease of leprosy can cause severe disability and disfigurement and is still a major health concern in many parts of the world. Only a subset of those individuals exposed to the pathogen will go on to develop clinical disease and there is a broad clinical spectrum amongst leprosy sufferers. The outcome of infection is in part due to host genes that influence control of the initial infection and the host's immune response to that infection. Identification of the host genes that influence host susceptibility/resistance will enable a greater understanding of disease pathogenesis. In turn, this should facilitate development of more effective therapeutics and vaccines. So far at least a dozen genes have been implicated in leprosy susceptibility and a genome-wide linkage study has lead to the identification of at least one positional candidate. These findings are reviewed here.

More information

Type
Journal Article
Author
Fitness J
Tosh K
Hill A V S
Year of Publication
2002
Journal
Genes and immunity
Volume
3
Issue
8
Number of Pages
441-53
Date Published
2002 Dec
Language
eng
ISSN Number
1466-4879
Call Number
FITNESS2002
DOI
10.1038/sj.gene.6363926
Alternate Journal
Genes Immun.
Publication Language
eng

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