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Publication

A family of dispersed repeats in Mycobacterium leprae.

Abstract

The genome of the causative agent of leprosy, Mycobacterium leprae, contains at least 28 copies of a dispersed repetitive sequence, RLEP. From nucleotide sequence analysis it was clear that the RLEP element consists of a 545 bp central domain flanked by a 100 bp left-end and a 44 bp right-end, sometimes associated with a 47 bp extension. The presence of the left and right ends is variable and this allowed three different RLEP configurations to be defined. When the polymerase chain reaction was used to study variation of the central region at least twelve different classes were detected, suggesting that no two RLEP sequences may be identical. Furthermore, they have few features in common with classical bacterial insertion sequences.

More information

Type
Journal Article
Author
Woods S A
Cole S T
Year of Publication
1990
Journal
Molecular microbiology
Volume
4
Issue
10
Number of Pages
1745-51
Date Published
1990 Oct
Language
eng
ISSN Number
0950-382X
DOI
10.1111/j.1365-2958.1990.tb00552.x
Alternate Journal
Mol. Microbiol.
Publication Language
eng