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Experimental Modeling of Leprosy in BALB/c, BALB/c Nude, CBA, and C57BL/6ТNF Mice.

Abstract

Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6ТNF mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed a temporal-quantitative dependence on the used mouse line. CBA and BALB/cNude mice were optimal for strain R and BALB/c and BALB/cNude lines were optimal for strain I. BALB/cNude mice infected with strain I had low lifespan. M. leprae strain M showed low proliferation activity in BALB/cNude and C57BL/6ТNF mice.

More information

Type
Journal Article
Author
Karamova A
Semenova V
Verbenko D
Obraztsova O
Vanchugova K
Nikonorov A
Deryabin D
Solomka V
Kubanov A
Year of Publication
2020
Journal
Bulletin of experimental biology and medicine
Date Published
10/2020
Language
eng
ISSN Number
1573-8221
DOI
10.1007/s10517-020-04991-7
Alternate Journal
Bull Exp Biol Med
PMID
33098510
Publication Language
eng

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