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Effect of Nigella Sativa Extract on Bacteriology Parameter of Multibacillar Leprosy Patients Administering MDT-WHO: Three Months Observation
Abstract
MDT-WHO implementation has decreased leprosy global prevalence. However, number of new cases
detected is still high. Therefore, new appropriate strategy, besides early detection and WHO-MDT treatment
which are the main strategies in leprosy eradication, is needed. The aim of this study was to investigate the
effects of Nigella sativa extract on bacteriology parameters of multibacillar leprosy patients administering
MDT-WHO. It was Double Blind - Randomized Controlled Trial study which was conducted in Jepara,
Central Java Province, Indonesia during February to June 2016. This study was performed on 60 eligible
multibacillar leprosy patients administering MDT-WHO. Bacterial index (BI) was measured using Ridley
logarithmic scale, whereas morphology index (MI) was measured as percentage of solid bacteria to the all
forms of bacteria. There was no subject who dropped out. The characteristics of subjects were similar between
the two groups, except for the MDT duration at baseline, where MDT duration in control group was longer.
There was no significant difference in BI proportion and MI proportion in the two groups after treatment.
Average BI in month 2 and 3 tend to be lower than control although not statistically significant. There were
significant differences of average BI decline between control and treatment groups in month 2 (p=0.000) and
month 3(p=0.005). There were statistically significant differences of average MI and average MI decline
between control and treatment groups in month 1 (p=0,000, p= 0.001, respectively). This study demonstrated
that Nigella sativa extract affected average MI and BI decline differences. Its efficacy as adjuvant therapy
might be confounded by duration of MDT-WHO.
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Type
Conference Proceedings